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Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers

Matthew V. Schulmerich,1 Kathryn A. Dooley,1 Michael D. Morris,1 Thomas M. Vanasse,2 and Steven A. Goldstein2
1University of Michigan, Department of Chemistry, Ann Arbor, Michigan 48109-1055
2University of Michigan Medical School, Orthopaedic Research Laboratories, Ann Arbor, MI 48109-2200

 

(Received 1 August 2006; revised 6 September 2006; accepted 18 September 2006; published online 13 December 2006)

Transcutaneous bone Raman spectroscopy with an exciting annulus of 785-nm laser light surrounding the field of view of a circular array of collection fibers is demonstrated. The configuration provides distributed laser light. The annulus is located 2  to  3  mm beyond the edge of the field of view of the collection fibers to reject contributions from skin and other overlying tissues. Data are presented for rat and chicken tissue. For rat tibia, the carbonate/phosphate ratio measured at a depth of 1  mm below the skin is in error by 2.3% at an integration time of 120  s and within 10% at a 30-s integration time. For chicken tibia 4  mm below the skin surface, the error is less than 8% with a 120-s integration time.

2006 Society of Photo-Optical Instrumentation Engineers

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Del Mar Photonics - Axicons in stock

Axicons in stock

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 Model   Product Name+   Price   Buy Now 
 AX-BK7-1-165-C   Axicon, BK-7, diam. 1", cone angle 165, BBAR 1000-1400 nm   $350.00  Buy Now 
 AX-BK7-1-165-1   Axicon, BK-7, diam. 1", cone angle 165, BBAR 400-700 nm   $350.00  Buy Now 
 AX-BK7-1-175-0   Axicon, BK-7, diam. 1", cone angle 175, uncoated   $290.00  Buy Now 
 AX-FS-1-140-1   Axicon, UV FS, diam. 1", cone angle 140, BBAR 400-700 nm   $350.00  Buy Now 
 AX-FS-1-140-C   Axicon, UV FS, diam. 1", cone angle 140, BBAR 660 nm   $350.00  Buy Now 
 AX-FS-1-140-2   Axicon, UV FS, diam. 1", cone angle 140, BBAR 700-1000 nm   $350.00  Buy Now 
 AX-FS-1-140-3   Axicon, UV FS, diam. 1", cone angle 140, BBAR 800&1064 nm   $350.00  Buy Now 
 AX-FS-1-140-0   Axicon, UV FS, diam. 1", cone angle 140, uncoated   $290.00  Buy Now 
 AX-FS-1-160-4   Axicon, UV FS, diam. 1", cone angle 160, BBAR 1100-1600 nm   $350.00  Buy Now 
 AX-FS-1-160-1   Axicon, UV FS, diam. 1", cone angle 160, BBAR 400-700 nm   $350.00  Buy Now 
 AX-FS-1-160-0   Axicon, UV FS, diam. 1", cone angle 160, uncoated   $290.00  Buy Now 
 AX-FS-1-165-4   Axicon, UV FS, diam. 1", cone angle 165, BBAR 1100-1600 nm   $350.00  Buy Now 
 AX-FS-1-165-1   Axicon, UV FS, diam. 1", cone angle 165, BBAR 400-700 nm   $350.00  Buy Now 
 AX-FS-1-165-3   Axicon, UV FS, diam. 1", cone angle 165, BBAR 800&1064 nm   $350.00  Buy Now 
 AX-FS-1-165-0   Axicon, UV FS, diam. 1", cone angle 165, uncoated   $290.00  Buy Now 
 AX-FS-1-170-4   Axicon, UV FS, diam. 1", cone angle 170, BBAR 1100-1600 nm   $350.00  Buy Now 
 AX-FS-1-170-1   Axicon, UV FS, diam. 1", cone angle 170, BBAR 400-700 nm   $350.00  Buy Now 
 AX-FS-1-170-0   Axicon, UV FS, diam. 1", cone angle 170, uncoated   $290.00  Buy Now 
 AX-FS-1-175-4   Axicon, UV FS, diam. 1", cone angle 175, BBAR 1100-1600 nm   $350.00  Buy Now 
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 AX-FS-1-175-2   Axicon, UV FS, diam. 1", cone angle 175, BBAR 700-1000 nm   $350.00  Buy Now 
 AX-FS-1-175-3   Axicon, UV FS, diam. 1", cone angle 175, BBAR 800&1064 nm   $350.00  Buy Now 
 AX-FS-1-175-0   Axicon, UV FS, diam. 1", cone angle 175, uncoated   $290.00  Buy Now 
 AX-FS-1-178-4   Axicon, UV FS, diam. 1", cone angle 178, BBAR 1100-1600 nm   $350.00  Buy Now 
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 AX-FS-1-178-2   Axicon, UV FS, diam. 1", cone angle 178, BBAR 700-1000 nm   $350.00  Buy Now 
 AX-FS-1-178-3   Axicon, UV FS, diam. 1", cone angle 178, BBAR 800&1064 nm   $350.00  Buy Now 
 AX-FS-1-179-4   Axicon, UV FS, diam. 1", cone angle 179, BBAR 1100-1600 nm   $350.00  Buy Now 
 AX-FS-1-179-2   Axicon, UV FS, diam. 1", cone angle 179, BBAR 700-1000 nm   $350.00  Buy Now 
 AX-FS-1-179-3   Axicon, UV FS, diam. 1", cone angle 179, BBAR 800&1064 nm   $350.00  Buy Now 
 AX-FS-1-179-0   Axicon, UV FS, diam. 1", cone angle 179, uncoated   $290.00  Buy Now 
 AX-FS-2-140-2   Axicon, UV FS, diam. 2", cone angle 140, BBAR 700-1000 nm   $700.00  Buy Now 
 AX-FS-2-160-C   Axicon, UV FS, diam. 2", cone angle 160, BBAR 800-1000 nm   $700.00  Buy Now 

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