Del Mar Photonics - Newsletter Fall 2010 - Newsletter Winter 2010
Photonics West 2011
Presentations by featured Del Mar Photonics' customers.
Inactivation of encephalomyocarditis virus and herpes simplex virus by using
a visible femtosecond laser
Paper 7895-28 of Conference 7895
Date: Wednesday, 26 January 2011
Time: 12:10 PM – 12:30 PM
Author(s): Shaw-Wei D. Tsen, Washington Univ. in St. Louis (United States);
Kong-Thon Tsen, Arizona State Univ. (United States)
Recently, a variety of viral systems, including M13 bacteriophage, tobacco
mosaic virus (TMV), human papillomavirus (HPV) and human immunodeficiency virus
(HIV) have been shown to be inactivated by the irradiation of a near-infrared
subpicosecond fiber laser. These experimental results indicated that the
inactivation of viruses by an ultrashort pulsed laser might involve disruption
of their protein coat through laser-induced excitation of large-amplitude
acoustic vibrations. In this work, we report experimental results on the
inactivation of both encephalomyocarditis virus (EMCV) and herpes simplex virus
(HSV) by using a visible femtosecond laser derived from the second harmonic
generation of a cw mode-locked Ti-sapphire laser system. The inactivation of
these viral particles has been demonstrated to depend on the laser exposure time
as well as laser power density. Possible mechanisms for the inactivation will be
discussed.