Del Mar Photonics - Potential Job Opportunities
Multidimensional IR Spectroscopy and Ultrafast Dynamics of
protein-ligand interaction
Many groups worldwide
investigates molecular dynamics and interactions at the intersection of
chemistry, physics and biology by cutting edge ultrafast nonlinear
spectroscopy, mainly multidimensional IR spectroscopy. The research is
highly interdisciplinary, involving the development of novel spectroscopic
tools as well as their application to photoswitchable designed biomolecules,
protein-ligand interaction, biomolecular folding, molecular interactions in
the liquid phase and chemical reaction dynamics.
The ideal candidate should therefore have a strong background and interest
in both ultrafast spectroscopic techniques as well as in biophysics or
physical chemistry.
Example of the project:
Developing new ultrafast dynamics tools for research in dynamics of molecules
of biological interest
The project aims at investigating dynamical properties of small biologically
relevant molecular systems in a well characterized environment with a strategy
following a step by step approach going from small model systems towards the
biological complexity. We want to study the relationship between
structure/conformation, dynamical properties and, in the long term, biological
function. The work will focus, but not exclusively, on carbohydrates, from the
simplest ones trapped in cryogenic solids towards larger and/or more complex
molecular assemblies and environments. These molecules feature a very large
conformational diversity and selectivity which make them play a central role in
molecular recognition processes. Their vibrational dynamics will be
studied at the pico- and femtosecond timescales by means of pump-probe
and photon echoes experiments, the optical analog methods to NMR. The
analysis of vibrational coherence, a very sensitive probe of environment
influence, will yield to information on the nature of the non-covalent
interactions underlying the fundamental processes of solvation, chemical
reactivity and biological function.
It is open to candidates with a strong background
of molecular physics or physical chemistry.
Experience with infrared spectroscopy, femto/picosecond laser as well as
being familiar with basic knowledge on vibrational coherence and
non-linear spectroscopy will be appreciated. Being acquainted to
cryogenic techniques can also be helpful.
Ultrafast Dynamics System
Del Mar Photonics offer complete Ultrafast Dynamics System. Examples of the table schematics is shown on the pictures:
Ultrafast Dynamics System includes:
Teahupoo Rider High Repetition Rate Amplified
Ti:Sapphire Laser
Beacon Up-Conversion Spectrometer
Hatteras Transient Absorption
Spectrometer
Femtosecond Harmonics
Generator
Teahupoo Rider and other options for Amplified
Ti:Sapphire Laser
1. We offer integrated oscillator/amplifier system
Teahupoo Rider. Teahupoo Rider is a fully-integrated all-in-one-box system
that includes Trestles Finesse oscillator
or Buccaneer SHG diode-pumped fiber oscillator,
pulse stretcher, regenerative amplifier pumped by
multi kHz Nd:YAG pump laser and pulse compressor. Teahupoo Rider has a
factory preinstalled repetition rate of 2, 5 or 10kHz and ideal for low cost
femtosecond micromachining systems, OPA pumping, ultrafast spectroscopy and
variety of applications in life sciences.
One-box system Trestles Finesse that include Trestles mini Ti:Sapphire oscillator and built in DPSS pump laser
When choosing specific Trestles Finesse model please indicate required CW pump power (4W or 6W), Ti:Sapphire pulse duration and required tuning range (or tuning range, where you want to achieve maximum performance)
Tuning range can be customized at the factory by choosing one of standard or custom made optics set. Typical tuning curves for 4W CW pump laser for two standard optics sets are shown in the Trestles Finesse brochure. For example, with 4W CW pump laser and long-wave mirrors set tuning range can be extended up to 940nm. With 6W CW pump laser tuning range can be extended up to 980nm.
2. If you already have a Ti:Sapphire oscillator, we can offer you stand alone Ti:Sapphire amplifier. Two standard models are available: Wedge M multipass or Wedge R regenerative.
Each amplifier is customized to the customer's amplifier pump laser.
2. Custom Teahupoo Rider systems with a pump
laser of your choice are also available. Depending on the required
specifications we can recommend a pump laser and make required adjustments for
optimum performance.
The following specifications can be achieved:
Repetition rate: single pulses, 10 Hz up to 10kHz
Pulse duration: 100fs, 50fs, 30fs, <30fs
Pulse energy: from 100 mJ per pulse to few mJ per
pulse
Tunability: both fixed wavelength and tunable options are available - please
indicate required tuning range.