Del Mar Photonics

Subject: Webcast Invitation - The Quantum Leap: Super-Resolution and Super-Sensitivity
Date: Wed, 23 Mar 2011 11:31:07 -0500 (CDT)

The Quantum Leap: Super-Resolution and Super-Sensitivity

NEW WEBCAST REGISTER NOW!
The Quantum Leap: Super-Resolution and Super-Sensitivity

Premieres LIVE: March 25, 2011

Register Now!

What You'll Learn:

* How and why the quantitative demands on biological imaging are increasing
* The knowledge gained through new research on functional networks and spatio-temporal organization in live cells and organisms
* The importance of detector sensitivity for research on photosensitive specimens
* How super-resolution microscopy, Hybrid detector technology, and fluorescence correlation spectroscopy (FCS) combine for synergistic effect.

Register Today!

Who Should Attend:
Everyone working with or interested in fluorescence light microscopy of all types (FCS, FLIM, etc). Life science researchers, biophysicists, cell biologists, geneticists, virologists, basic medical researchers, and pharmacologists; principal investigators, professors, and PhD students.

Need More Details?
When: March 25, 2011
Time: 10:00 AM EDT | 7:00 AM PDT | 2:00 PM GMT

PRESENTERS:
Dr. Spencer L. Shorte
Plateforme d'Imagerie Dynamique (PFID), Imagopole Institut Pasteur, Paris, France Dr. Christian Eggeling
Department for Nanobiophotonics, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany

PRODUCED BY: PennWell

2011 Yale Microscopy Workshop
Multimodal Nonlinear Optical Microscopy Workshop

Del Mar Photonics Tresltes LH laser used for STED microscopy of nanodiamons

Trestles LH femtosecond lasers with integrated DPSS DMPLH laser pump - DPSS DMP LH series advantages

Trestles LH10-fs/CW laser system at UC Santa Cruz Center of Nanoscale Optofluidics

More about nanodiamonds

Detonation nanodiamond
Nano-Diamond Discovery Suggests a Comet Impact Killed the Mammoths
What Killed the Mammoths? Alien Nanodiamonds May Hold the Answer
Nanodiamonds are a neuron’s best friend
Nanodiamond Drug Device Could Transform Cancer Treatment

... in their study, Ho and his colleagues embedded millions of tiny drug-carrying nanodiamonds in the FDA-approved polymer parylene. Currently used as a coating for implants, the biostable parylene is a flexible and versatile material resembling plastic wrap. A substantial amount of drug can be loaded onto clusters of nanodiamonds, which have a high surface area. The nanodiamonds then are put between extremely thin films of parylene, resulting in a device that is minimally invasive...

Nanodiamond conjugate induces cancer cell death and inhibits tumorigenesis

Researchers in Taiwan have manipulated nanodiamond (ND), a carbon nanomaterial, to covalently link paclitaxel for cancer drug delivery and therapy. Paclitaxel was bound to the surface of 3–5 nm sized ND through a succession of chemical modifications. The ND-paclitaxel conjugation was measured by atomic force microscopy and nuclear magnetic resonance spectroscopy, and confirmed with infrared spectroscopy by the detection of deuterated paclitaxel.

Trestles LH10-fs/CW laser system

Typical specifications are:

Trestles LH10-fs/CW laser system Request a quote
Ti:Sapphire femtosecond oscillator with CW operation option
Spatial mode: TEMoo;
Polarization: linear horizontal;
fs mode:
Tuning range (@10W pump): 750-850 nm;
Output power (@10W pump, 800 nm): >1500 mW;
Repetition rate: 80 MHz;
Pulse duration: <100 fs;
CW mode:
Tuning range (@10W pump): 750-850 nm;
Output power (@10W pump, 800 nm): >2000 mW in CW;
Linewidth (with two etalons): <2 GHz
Also included:
Thermostabilized breadboard;
Electronic starter with TTL output for mode-locked mode observation;
USB-controlled tuning slit for wavelength tuning in fs mode;
3-plate USB-controlled birefringent Lyot filter;
Two motorized USB-controlled etalons for linewidth control

DPSS LH10 (10 Watt Diode Pump Solid State Laser)
Average Output Power > 10 W
Wavelength 532 nm
Spectral Purity > 99.9 %
Spatial Mode TEM00
Beam Quality (M2) 1.0 - 1.1
Beam Ellipcicity < 1.0 : 1.1
Beam Diameter 2.3 mm ± 10%
Beam Divergence < 0.5 mrad
Pointing Stability < 2 μrad/°C
Power Stability < ± 0.25 % rms
Noise Standard version: < 0.2 % rms
Low noise (NET) version: < 0.03 % rms
Polarization > 100:1 vertical
Power Requirements
Operating Voltage 100-240 VAC, 50 Hz / 60 Hz
Power Consumption 500 W max, 300 W typical
Cooling Requirements
Laser Head Closed-loop chiller in Power Supply - Cooler
Power Supply (in Power Supply - Cooler) Air-cooled
Environmental Specifications
Operating Temperature 64-90°F (18-32°C)
Relative Humidity 8-85%, non-condensing
Laser Head - Physical Dimensions (Height x Width x Length)
2.7 x 5.3 x 10.1 inches
(69 x 135 x 256 mm)
Weight 7.0 lbs (3.2 kg) approx.
Cable Length 10 " (3 m)
Power Supply-Cooler - Physical Dimensions (Height x Width x Depth)
13.0 x 12.7 x 18.2 inches
(330 x 323 x 463 mm)
Weight 55 lbs (25 kg) approx.

Trestles fs-CW manual

Schematic setup of Trestles LH10-fs/CW laser system with built-in pump laser

Del Mar Photonics supply Trestles lasers as stand alone system, or as a one-box system with built-in DPSS pump laser.
The price of the system with DPSS pump depends on required output power.

The standard tuning elements indicated below are used in CW Ti:Sapphire lasers such as Trestles CW or Trestles fs/CW.

Those elements are also sold separately as standrad items or as a custom made components.

1) Thick etalon - request a quote
Thickness - 3 mm, diameter - 20 mm. Surface quality: Ð=1-2, N<1, ΔN<0.1,
λ/10, plane parallelism better than 10''. Thickness accuracy 5 um.

2) Thin etalon - request a quote
Thickness - 200 um, diameter - 15 mm. Surface quality: Ð=1-2, N<1, ΔN<0.1,
λ/10, plane parallelism better than 10''. Thickness accuracy 5 um.

3) Birefringent filter BRF - request a quote

We use a 3-plate assembled BRF (Lyot filter) with adjustable motorized mount (see attached drawing).

Total losses introduced into the cavity by the filter are 5% of the laser’s output power. The FSR is defined by the thinnest plate and equals to around - 1.3*10¹⁴ Hz, while the maximum width is controlled by the thickest plate and equals to approx. 3.1*10¹² Hz.

Dimensions of plate assembly ('filter' in the picture): dia 44.5 mm, t=13.5 mm. It should be properly aligned (Brewster to the beam) and rotated by some rotating mount around its axis to provide wavelength tuning.

Trestles LH femtosecond lasers with integrated DPSS DMPLH laser pump - DPSS DMP LH series advantages

Trestles LH10-fs/CW laser system at UC Santa Cruz Center of Nanoscale Optofluidics

Del Mar Photonics, Inc.
4119 Twilight Ridge
San Diego, CA 92130
tel: (858) 876-3133
fax: (858) 630-2376
Skype: delmarphotonics
sales@dmphotonics.com