Del Mar Photonics - Newsletter Winter 2010 - Newsletter April 2011
Del Mar Photonics supplies multi-photon lasers and systems based on cost effective femtosecond sources:
Detecting Nephrotoxicity Using Early Markers and Imaging Tools
June 7 - 8, 2011 | Philadelphia, PA | WorldPharmaCongress.com/NTX
Cisplatin Nephrotoxicity and Renal Protective Strategies
Zheng Dong, Ph.D., Professor, Department of Cellular Biology and Anatomy, Medical College of Georgia
Primary Cell Cultures from Human and Rat Proximal Tubule as Models to Study Mechanisms of Acute Kidney Injury
Lawrence H. Lash, Ph.D., Professor, Associate Chair, Pharmacology, School of Medicine, Wayne State University
MONITORING AND ASSESSING KIDNEY INJURY
Current Use of Renal Biomarkers in Early Drug Development
Diann Weddle, Ph.D., D.V.M., Senior Pathologist, Pre-Clinical Safety, Abbott Laboratories
Pre-Clinical Biomarkers of Nephrotoxicity: Applications in Drug Discovery and Development
Eric Blomme, D.V.M., Ph.D., D.A.C.V.P., Senior Project Leader, Abbott Laboratories
Integrative Assessment of Drug-Induced Kidney Function Changes and Acute Injury Using an Automated Blood Sampling and Telemetry (ABST) System
Yafei Chen, M.D., M.S., Scientist Safety Pharmacology, Global Safety Assessment, AstraZeneca Pharmaceuticals
KIDNEY MARKERS: FROM BENCH TO BEDSIDE
FEATURED PRESENTATION: Establishing the Context for Introducing New Safety Biomarkers into Clinical Trials
Stephen Furlong, Ph.D., Safety Science Lead, U.S., Patient Safety, AstraZeneca
Clinical Evaluation and Qualification of Kidney Safety Biomarkers: A Collaboration between Two Consortia
Maria Vassileva, Ph.D., Scientific Program Manager, The Biomarkers Consortium, Foundation for the NIH
Urinary Cytokines as Biomarkers of Nephrotoxicity
W. Brian Reeves, M.D., F.A.C.P., Chief, Division of Nephrology, Professor and Vice Chair, Medicine, Penn State College of Medicine
Rapid Point-of-Care GFR: Technique, Diagnostic and Therapeutic Advantages
Bruce A. Molitoris, M.D., Director, Division of Nephrology and Professor of Medicine, Indiana University
PANEL DISCUSSION: Renal Injury Markers and How Effectively Can They Be Used?
Moderator: W. Brian Reeves, M.D., F.A.C.P., Chief, Nephrology; Professor and Vice Chair, Medicine, Penn State College of Medicine
MITOCHONDIRAL INVOLVEMENT IN CARDIAC, RENAL AND LIVER TOXICITY
Introduction to Mitochondrial Function and Drug-Induced Dysfunction
James Dykens, Ph.D., CEO, EyeCyte Therapeutics
Tales of Broken Mitochondria: Drug-Induced Cardiac Mitochondrionopathy
Paulo Oliveira, Ph.D., Group Leader, Mitochondrial Toxicology and Disease, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal and Visiting Research Associate, University of Minnesota Medical School
Mitochondrial Homeostasis in Acute Kidney Injury
Rick Schnellmann, Ph.D., Professor, Chair, Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy
Mechanistic Insights into Mitochondrial-Based Organ Toxicity
Yvonne Will, Ph.D., Associate Research Fellow, Compound Safety Prediction, Pfizer Global R&D
PANEL: Strategies for Assessing Mitochondrial Involvement in Drug-Induced Organ Toxicities
Moderator: Yvonne Will, Ph.D., Associate Research Fellow, Compound Safety Prediction, Pfizer Global R&D
RECOMMENDED SHORT COURSES* View Short Course offerings.
Monday, June 6 | 9:00am - 12:00pm
Use of Stem Cells for Safety Screening
The course provides new insights into the use of embryonic and pluripotent stem cells for drug safety testing, especially cardiac safety.
=Differentiation of human stem cells into cardiac myocytes
=Comparison of electrophysiology and pharmacology
=Overcoming technical challenges related to working with stem cells
=Methodologies to maintain and use stem cells for predictive safety testing
Craig T. January, M.D., Ph.D., Professor, Medicine and Physiology, Division of Cardiovascular Medicine, University of Wisconsin, Madison
Monday, June 6 | 2:00pm - 5:00pm
Translating Safety Biomarkers from the Lab to the Clinic
The course offers a unique and practical perspective for successfully translating the pre-clinical work done for testing and validating safety biomarkers to the clinic.
=Design and implementation of studies to identify new biomarkers
=Designing clinical studies to test and validate biomarkers
=Clinical methodologies for cost-effective and reliable decision-making
=Bridging the gap between pre-clinical and clinical findings
=Practical considerations when using biomarkers in the clinic
=Points to consider for a successful transfer from the lab to the clinic
Stephen Furlong, Ph.D., Safety Science Lead, U.S., Patient Safety, AstraZeneca
William B. Mattes, Ph.D., DABT, Independent Consultant, PharmPoint Consulting
Monday, June 6 | 2:00pm - 5:00pm
Addressing Safety Concerns for Biological Drugs
The course offers guidance from experts in the field on what is being used and looked at for early safety assessments for biological molecules, and how these early predictions are then being applied for clinical testing.
=Overview of challenges pertaining to the safety of biologics
=Tools, markers and assays for early safety predictions
=Assessing immunogenicity and off-target effects
=Regulatory guidelines and their interpretations
=Criteria for determining what needs to be tested and when
Lisa M. Plitnick, Ph.D., Senior Investigator, Safety Assessment, Merck & Co., Inc.
Noël Dybdal, Ph.D., D.V.M., Associate Director, Principal Scientist, Safety Assessment, Genentech, Inc.
Vivek Kadambi, Ph.D., Senior Director, Drug Safety Evaluation, Millennium, The Takeda Oncology Company
Del Mar Photonics - Del Mar Photonics Summer Sale - Best price quarantee!
Product news and updates - Training Workshops - Featured Customer - Other News
| Trestles LH Ti:Sapphire
Trestles LH is a new series of high quality femtosecond Ti:Sapphire lasers for applications in scientific research, biological imaging, life sciences and precision material processing. Trestles LH includes integrated sealed, turn-key, cost-effective, diode-pumped solid-state (DPSS). Trestles LH lasers offer the most attractive pricing on the market combined with excellent performance and reliability. DPSS LH is a state-of-the-art laser designed for today’s applications. It combines superb performance and tremendous value for today’s market and has numerous advantages over all other DPSS lasers suitable for Ti:Sapphire pumping. Trestles LH can be customized to fit customer requirements and budget.
DPSS DMPLH lasers
Pismo pulse picker
The Pismo pulse picker systems is as a pulse gating system that lets single pulses or group of subsequent pulses from a femtosecond or picosecond pulse train pass through the system, and stops other radiation. The system is perfectly suitable for most commercial femtosecond oscillators and amplifiers. The system can pick either single pulses, shoot bursts (patterns of single pulses) or pick group of subsequent pulses (wider square-shaped HV pulse modification). HV pulse duration (i.e. gate open time) is 10 ns in the default Pismo 8/1 model, but can be customized from 3 to 1250 ns upon request or made variable. The frequency of the picked pulses starts with single shot to 1 kHz for the basic model, and goes up to 100 kHz for the most advanced one.
The Pockels cell is supplied with a control unit that is capable of synching to the optical pulse train via a built-in photodetector unit, while electric trigger signal is also accepted. Two additional delay channels are available for synching of other equipment to the pulse picker operation. Moreover, USB connectivity and LabView-compatible drivers save a great deal of your time on storing and recalling presets, and setting up some automated experimental setups. One control unit is capable of driving of up to 3 Pockels cells, and this comes handy in complex setups or contrast-improving schemes. The system can also be modified to supply two HV pulses to one Pockels cell unit, making it a 2-channel pulse picker system. This may be essential for injection/ejection purposes when building a regenerative or multipass amplifier system.
Tourmaline Yb-SS-1058/100 Femtosecond solid state laser system
The Yb-doped Tourmaline Yb-SS laser radiates at 1058±2 nm with more than 1 W of average power, and enables the user to enjoy Ti:Sapphire level power at over-micron wavelengths. This new design from Del Mar's engineers features an integrated pump diode module for greater system stability and turn-key operation. The solid bulk body of the laser ensures maximum rigidity, while self-starting design provides for easy "plug-and-play" operation.
|New laser spectrometer
T&D-scan for research that
demands high resolution and high spectral
density in UV-VIS-NIR spectral domains - now available with
new pump option!
The T&D-scan includes a CW ultra-wide-tunable narrow-line laser, high-precision wavelength meter, an electronic control unit driven through USB interface as well as a software package. Novel advanced design of the fundamental laser component implements efficient intra-cavity frequency doubling as well as provides a state-of-the-art combined ultra-wide-tunable Ti:Sapphire & Dye laser capable of covering together a super-broad spectral range between 275 and 1100 nm. Wavelength selection components as well as the position of the non-linear crystal are precisely tuned by a closed-loop control system, which incorporates highly accurate wavelength meter.
Near IR viewers
Ultraviolet viewers are designed to observe radiation emitted by UV sources.
AOTF Infrared Spectrometer
Open Microchannel Plate Detector
now in stock!
|Hummingbird EMCCD camera
The digital Hummingbird EMCCD camera combines high sensitivity, speed and high resolution.
It uses Texas Instruments' 1MegaPixel Frame Transfer Impactron device which provides QE up to 65%.
Hummingbird comes with a standard CameraLink output.
It is the smallest and most rugged 1MP EMCCD camera in the world.
It is ideally suited for any low imaging application such as hyperspectral imaging, X-ray imaging, Astronomy and low light surveillance.
It is small, lightweight, low power and is therefore the ideal camera for OEM and integrators.
femtosecond transient absorption data acquisition system
Future nanostructures and biological nanosystems will take advantage not only of the small dimensions of the objects but of the specific way of interaction between nano-objects. The interactions of building blocks within these nanosystems will be studied and optimized on the femtosecond time scale - says Sergey Egorov, President and CEO of Del Mar Photonics, Inc. Thus we put a lot of our efforts and resources into the development of new Ultrafast Dynamics Tools such as our Femtosecond Transient Absorption Measurements system Hatteras. Whether you want to create a new photovoltaic system that will efficiently convert photon energy in charge separation, or build a molecular complex that will dump photon energy into local heat to kill cancer cells, or create a new fluorescent probe for FRET microscopy, understanding of internal dynamics on femtosecond time scale is utterly important and requires advanced measurement techniques.
spot in our Ultrafast Dynamics Tools
training workshop in San Diego, California.
spot in our Ultrafast Dynamics Tools
training workshop in San Diego, California.
Wavefront Sensors: ShaH Family
A family of ShaH wavefront sensors represents recent progress of Del Mar Photonics in Shack-Hartmann-based technology. The performance of Shack-Hartmann sensors greatly depends on the quality of the lenslet arrays used. Del Mar Photonics. developed a proprietary process of lenslet manufacturing, ensuring excellent quality of refractive lenslet arrays. The arrays can be AR coated on both sides without interfering with the micro-lens surface accuracy. Another advantage of the ShaH wavefront sensors is a highly optimized processing code. This makes possible real-time processing of the sensor data at the rate exceeding 1000 frames per second with a common PC. Due to utilizing low-level programming of the video GPU, it is possible to output the wavefront data with a resolution up to 512x512 pixels at a 500+ Hz frame rate. This mode is favorable for controlling modern LCOS wavefront correctors.
The family of ShaH wavefront sensors includes several prototype models, starting from low-cost ShaH-0620 suitable for teaching laboratory to a high-end high-speed model, ShaH-03500. The latter utilizes a back-illuminated EM-gain CCD sensor with cooling down to -100°C. This makes it possible to apply such a wavefront sensor in astronomy, remote sensing, etc.
Terahertz systems, set ups and components New band pass and long pass THz optical filters based on porous silicon and metal mesh technologies. Band pass filters with center wavelengths from 30 THz into GHz range and transmissions up to 80% or better. Standard designs with clear aperture diameters from 12.5 to 37.5 mm. Long pass filters with standard rejection edge wavelengths from 60 THz into GHz range. Maximum transmission up to 80% or better, standard designs at 19.0 and 25.4 mm diameters. Excellent thermal (from cryogenic to 600 K) and mechanical properties THz products: Portable Terahertz Source THz Spectrometer kit with Antenna THz transmission setup THz time domain spectrometer Pacifica fs1060pca THz time domain spectrometer Pacifica fs780pca THz detectors: Golay cell and LiTaO3 piroelectric detectors PCA - Photoconductive Antenna as THz photomixer Pacifica THz Time Domain Spectrometer - Trestles Pacifica Holographic Fourier Transform Spectrometer for THz Region Wedge TiSapphire Multipass Amplifier System - THz pulses generation Terahertz Spectroscopic Radar Mobile System for Detection of Concealed Explosives Band pass filters with center wavelengths from 30 THz into GHz range Long pass filters with standard rejection edge wavelengths from 60 THz into GHz range Generation of THz radiation using lithium niobate Terahertz crystals (THz): ZnTe, GaAs, GaP, LiNbO3 - Wedge ZnTe Silicon Viewports for THz radiation Aspheric collimating silicon lens - Aspheric focusing silicon lens
iPCA - interdigital Photoconductive Antenna for terahertz waves
Large area broadband antenna with lens array and high emitter conversion efficiency
iPCA with LT-GaAs absorber, microlens array for laser excitation wavelengths l £ 850 nm, adjusted hyperhemispherical silicon lens with a high power conversion efficiency of 0.2 mW THz power / W optical power. The iPCA can be used also as large area THz detector. The two types iPCAp and iPCAs have the same active interdigital antenna area but different contact pad directions with respect to the electrical THz field.
Interdigital Photoconductive Antenna for terahertz waves generation using femtosecond Ti:Sapphire laser
|Fifth Harmonic Generator for
The Fifth Harmonic Generator model LG105 is compatible with any pulsed Nd:YAG laser, and is designed to produce UV-radiation at 213 nm. The
Nd:YAG laser, equipped with LG105, is a versatile device, and in many applications can eliminate the necessity for excimer lasers. Solid state technology that does not use toxic gases and costs less gives you the advantages of both consistent, day-to-day operation and low maintenance. A high quality BBO crystal is used in the LG105 as the non-linear element, providing up to 20% conversion efficiency into 213 nm. The non-linear crystal is placed in a special cell ensuring long lifetime of BBO without any degradation or breakage. A harmonic separation system installed in LG105 provides nearly 100 % spectral purity of the output at 213 nm. The LG105 Fifth Harmonic Generator gives you not only high power output but also excellent radiation stability
|IntraStage lowers the cost
of test data management!
Struggling with gigabytes or terabytes of test data?
IntraStage easily transforms test data from disparate sources into web-based quality metrics and engineering intelligence you can use.
us today to discuss your test management requirements and specifications of your
|Come to San Diego next summer! Attend one of our training workshops in San Diego, California
during summer 2011
Del Mar Photonics has presented training workshops for customers and potential customers in the past 3 years.
Our workshops cover scientific basics, technical details and provide generous time for hands-on training.
Each workshop is a three-day seminar conducted by professional lecturer from 10am to 4pm. It includes lunch, as well as a training materials. We have also reserved two days for Q&A sessions, one-on-one system integration discussions, social networking, and San Diego sightseeing.
The following training workshops will be offered during this
Mar Photonics offers new
Trestles fs/CW laser system which can be easily
switched from femtosecond mode to CW and back. Having both modes of operation in one system dramatically increase a
number of applications that the laser can be used for, and makes it an ideal
tool for scientific lab involved in multiple research projects.
Frequency-stabilized CW single-frequency ring Dye laser DYE-SF-007 pumped by DPSS DMPLH laser installed in the brand new group of Dr. Dajun Wang at the The Chinese University of Hong Kong.
DYE-SF-077 features exceptionally narrow generation line width, which amounts to less than 100 kHz. DYE-SF-077 sets new standard for generation line width of commercial lasers. Prior to this model, the narrowest line-width of commercial dye lasers was as broad as 500 kHz - 1 MHz. It is necessary to note that the 100-kHz line-width is achieved in DYE-SF-077 without the use of an acousto-optical modulator, which, as a rule, complicates the design and introduces additional losses. A specially designed ultra-fast PZT is used for efficient suppression of radiation frequency fluctuations in a broad frequency range. DYE-SF-077 will be used in resaerch of Ultracold polar molecules, Bose-Einstein condensate and quantum degenerate Fermi gas and High resolution spectroscopy
Optical Society of Southern California meeting at UCSD OSSC 2011-04-27
Nd:YAG laser ordered by the University of Leon, UANL, Mexico
Wedge 50 Multipass Amplifier pumped with a Darwin-527-30-M DPSS Laser ordered by Hong Kong customer
New Trestles LH10-fs/CW femtosecond+CW laser ready for delivery to the University of California Santa Cruz
Trestles femtosecond Ti:Sapphire laser delivered to North Carolina State University
Del Mar Photonics sponsor IONS (International OSA Network of Students) conference IONS-NA-2 in Tucson, Arizona IONS-NA-2 website
Best talk and best poster awards at IONS-Moscow 2010 conference sponsored by Del Mar Photonics
Watch Del Mar Photonics videos!
Del Mar Photonics is now on Twitter!
Del Mar Photonics featured components
Del Mar Photonics continuously expands its components portfolio.
Prisms for Concentrating Photovoltaic Systems (CPV)
Solar cells made of compound semiconductors such as gallium arsenide are very expensive. Usually very small cells are installed and various means such as mirrors, lenses, prisms, etc..are used to concentrate sunlight on the cells. Concentration photovoltaic technology (CPV) uses the solar radiation with an efficiency of 40%, double that of conventional solar cells
Del Mar Photonics design custom Concentrating Photovoltaic Systems (CPV) and supply variety of the optical components for CPV such as solar prisms shown in the picture.
Axicon lens also known as conical lens or rotationally symmetric prism is widely used in different scientific research and application. Axicon can be used to convert a parallel laser beam into a ring, to create a non diffractive Bessel beam or to focus a parallel beam into long focus depth.
Del Mar Photonics supplies axicons with cone angles range from 130° to 179.5° for use with virtually any laser radiation. We manufacture and supply axicons made from BK7 glass, fused silica and other materials.
download brochure - request a quote
Rutile (TiO2) coupling
Del Mar Photonics offers optical elements made of high quality synthetically grown Rutile Titanium Dioxide crystals. Rutile’s strong birefringency, wide transmission range and good mechanical properties make it suitable for fabrication of polarizing cubes, prisms and optical isolators. Boules having high optical transmission and homogeneity are grown by proprietary method. Typical boules have 10 - 15 mm in dia. and up to 25 mm length. Optical elements sizes - from 2 x 2 x 1 mm to 12.7 x 12.7 x 12.7 mm. Laser grade polish quality is available for finished elements. So far we the largest elements that we manufactured are 12 x15 x 5 mm, in which optical axis is parallel to 15 mm edge, 5 mm is along beam path, 12 x 15 mm faces polished 20/10 S/D, one wave flatness, parallelism < 3 arc.min. (better specs. available on request).
more details - download brochure - request a quote
Sapphire Circular Windows - Square & Rectangle - Rods
Sapphire & Ruby Rings - Sapphire & Ruby Balls - Sapphire & Ruby Nozzles
Sapphire Lenses - Ball & Seat - Special Products - Sapphire Vee & Cup Jewels
Sapphire Ceramics - Ceramic Sleeves - Ceramic Holes - Ceramic Rods
Sapphire & Ruby Orifices - Sapphire & Ruby Tubes - Sapphire Components
Sapphire Half Round Rod - Sapphire Windows - Rods ＆ Tubes - Special Part
Sapphire Prism - Sapphire Chisel - Sapphire Square Rod
Del Mar Photonics offer a range of competitively priced UHV viewports , Conflat, ISO or KF including a variety of coatings to enhance performance. Del Mar Photonics viewports are manufactured using advanced techniques for control of special and critical processes, including 100 percent helium leak testing and x-ray measurements for metallization control. Windows Materials include: Fused silica, Quartz , Sapphire , MgF2, BaF2, CaF2, ZnSe, ZnS, Ge, Si, Pyrex. Standard Viewing diameters from .55" to 1.94 ".
Coating - a range of custom coatings can applied - which include
- Single QWOT
- Broad Band AR
- V coatings
- DLC (Diamond like coating)
more details - request a quote
NARROW-BAND HOLOGRAPHIC FILTERS are intended for suppression of powerful beams in research and in engineering, in particular, in laser spectroscopy, and also for protection from blinding and damaging by laser radiation various photo receiver devices and operator's eyes.
Unlike conventional interference filters, which are made by vacuum evaporation techniques, holographic filters are fabricated by recording interference patterns formed between two mutually coherent laser beams. Since all layers are recorded simultaneously within a thick stack, the optical density of the notch filter is high and its spectral bandwidth can be extremely narrow. Also, since the layering profile is sinusoidal instead of square wave, holographic notch filters are free from extraneous reflection bands and provide significantly higher laser damage thresholds.
Thyratrons are used in
such devices as radars with different power levels, high-power pulsed
technical, electrophysical, medical devices and lasers. Sophisticated
design and high quality ceramic-metal envelope determines long lifetime
and very accurate and reliable operation of hydrogen thyratrons under wide range of environmental
- pulsed lasers power supplies
- medical apparatus
- electrophysical instrumentation
Triggered Three-Electrode Spark Gap Switches are ceramic-metal sealed off gas discharge trigatron-type devices with a co-axial trigger electrode. These Gas Discharge Tubes contain no mercury and, due to an advanced design, feature high reliability and a long lifetime being operating under wide range of environmental conditions.
- pulsed installation for processing materials
- installations with plasma focus
- pulse power supplies for lasers and other pulse equipment
- medical apparatus such as lithotriptors and defibrillators
- processing systems for petroleum wells
Del Mar Photonics supply trigger transformers for triggered spark gaps and other applications. Contact us to today to discuss your application or requesta quote.
Trigger Transformers are used to provide a fast high voltage pulse up to 30kV/µs and more. This high voltage pulse is applied to the trigger electrode to initiate switching action in the three-electrode spark gaps. Either positive or negative pulses can be obtained from all of the transformers.
|We are looking forward to hear from you and help you with your optical and crystal components requirements. Need time to think about it? Drop us a line and we'll send you beautiful Del Mar Photonics mug (or two) so you can have a tea party with your colleagues and discuss your potential needs.|
Del Mar Photonics, Inc.
4119 Twilight Ridge
San Diego, CA 92130
tel: (858) 876-3133
fax: (858) 630-2376